By a process fertility of female offspring smoking during pregnancy has many negative effects on fetal development click to follow . A new study in mice by Andrea Jurisicova and colleagues at the University of Toronto , adds now the possibility that smoking before pregnancy or during breast-feeding can significantly decrease fertility in female offspring of the long list of potential negative consequences.
The authors found that female mice injected under the skin with polycyclic aromatic hydrocarbons – environmental toxins contained in cigarette smoke – pre – pregancy or while breastfeeding, it was found that normal sized litters. Cell clusters , each containing a single egg – but their female offspring had number of the number of resting and early growing follicles. Further analysis showed that the effects of the number of follicles in PAHs female offspring by aryl hydrocarbon receptor , the up-regulated expression of the gene encoding a protein Harakiri, the cells, by a process die as apoptosis mediated effects were making. The potential importance of these findings for women of childbearing age was shown by the observation that PAHs triggered similar molecular pathways in human ovarian tissue transplanted into immunocompromised mice.