About TLR inhibitorsDynavax endosomal TLR inhibitors are a new class of oligonucleotides.

About TLR inhibitorsDynavax endosomal TLR inhibitors are a new class of oligonucleotides, called immunoregulatory sequences , which specifically inhibit the TLR – induced inflammatory response associated with autoimmune and inflammatory diseases. Preclinical data from animal model studies show Dynavax’s TLR inhibitors block the induction of IFN – alpha and also the symptoms in several animal models of autoimmune diseases, such as lupus, inflammatory skin disease and rheumatoid arthritis..

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