PG110 is currently in a Phase 1 clinical trial in patients with osteoarthritis and represents a promising fresh therapeutic for the treatment of chronic pain. The agreement includes an upfront payment of $170 million plus additional milestone obligations, for a total as high as $190 million. They did an extraordinary job of building this business from the bottom up and the acquisition of this antibody by Abbott is testament to their knowledge in the therapeutic antibody development field. There are an estimated 72 million diagnosed chronic pain patients in the U.S. And EU and up to 30 % of chronic pain patients get inadequate relief. Current treatments consist of NSAIDs, selective Cox-2 inhibitors, opioids, and additional analgesics that are dosed daily and also have various protection and tolerability issues, including the prospect of addiction and abuse.The administration of pulsatile GnRH for seven days induced robust increases in degrees of gonadotropins and estradiol as well as the development of a dominant ovarian follicle, noticed on ultrasonography . Although the secretion of luteinizing hormone improved in response to the administration of GnRH, the typical peaked design of luteinizing hormone pulses21 was not seen, which recommended a degree of pituitary dysfunction. Certainly, the patient’s pituitary responsiveness waned as time passes, with a lower life expectancy response to GnRH on day time 1 of treatment 15 months after the initial endocrine study .