Published in the recent issue of Nature Biotechnology and supported by National Institute of Health.

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So, what goes wrong when FHL1 is mutated? In RBM called mutant FHL1 accumulates in cytoplasmic aggregates reduction body, probably as a result of incorrect folding. When these made brought in cultured myoblasts to express, but also aggregated and did not induce hypertrophy. Cowling and colleagues found that NFATc1 was seized to the aggregates and hence was able to activate its target genes.

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