Regarding each one of these issues, the subcutaneous ICD program was adjusted soon after implantation in an effort to improve the system’s reliability. Issues with lead dislodgment have led to the launch of an anchoring sleeve and a new surgical technique. Inappropriate sensing offers been addressed through software revision, with no incidents in the 3 months after revision. Nevertheless, these modifications will demand further testing in additional groups of patients. Ultimately, the relative benefit of subcutaneous ICDs, in comparison with transvenous ICDs, will need to be shown in large, long-term, randomized, potential, multicenter clinical trials. In addition, there are inherent limitations of the device design. Although transient post-shock pacing is obtainable, the subcutaneous ICD cannot provide long-term pacing.Understanding this, Co-workers and Beattie plan to study other proteins that might rely on SMN for their production. This is informing us that probably SMN is affecting translation of other proteins that may be contributing to spinal muscular atrophy. That was not shown before, Beattie said. An examination of zebrafish motor neurons suggested that reduced plastin 3 impacts these cells in at least two methods: by damaging axons, branch-like extensions that allow for conversation among nerve cells, and by destabilizing synapses, structures through which those signals move, Beattie said. She and colleagues also examined seafood behavior connected with protein changes.