TITLE: disruption of the leptin receptor expression in the pancreas directly affects beta cell growth and function in miceAUTHOR CONTACT: Rohit N. Kulkarni Joslin Diabetes Center, Massachusetts,TITLE: Obesity and the beta cell: Lessons from LeptinAUTHOR CONTACT: Mark A. Magnuson Vanderbilt University School of Medicine, Nashville, Tennessee,work FGF2 and PDGF-BB promote tumor growth promote tumor growthtumor growth and metastasis of the tumor developed requires a separate network of blood vessels, a process known as neovascularization sneezing . Agents produced a factor of tumors neovascularization neovascularization, VEGF, have some success in the clinic. However, tumors often produce several factors that promote angiogenesis. A new study on mice by Yihai Cao and colleagues at the Karolinska Institute, Sweden, has shown that there is produces the collaboration between two factors of many tumors neovascularization neovascularization, FGF2 and PDGF-BB. The clinical relevance of of this study – that targeting more than one molecule may be necessary to successfully treat people with cancer. In the accompanying in the accompanying commentary by Jack Arbiser of Emory University School of Medicine, Atlanta.
TITLE: CX3CR1 – dependent subretinal microglia cell accumulation with cardinal features of age-related macular degenerationAUTHOR CONTACT: Florian Sennlaub Centre de recherche des Cordeliers, France.Christophe Combadi re INSERM U543, decyne Piti? – Salp? France.TITLE: Overstaying their welcome: defective CX3CR1 microglia eyed in macular degenerationAUTHOR CONTACT: Lois EH Smith Hospital for Children, Massachusetts,On the edge: Bnip3 heart cells caused to the premises from a heart attack to diepersons myocardial infarction.ardial infarction. A heart attack, have a high risk for the development of chronic heart failure, because the heart tissue transformed, that is, it undergoes changes in the size, shape and function. The death of heart muscle cells by a process known as apoptosis is thought to have an important role in cardiac remodeling after myocardial infarction.
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