Evaluation of other covariates is referred to in the Supplementary Appendix, obtainable with the full text of this content at NEJM.org. Clinical End Points Ischemic vascular disease was thought as either ischemic cardiovascular disease or ischemic cerebrovascular disease. Info on diagnoses of ischemic cardiovascular disease and ischemic cerebrovascular disease was collected and verified through an assessment of all medical center admissions and diagnoses entered in the Danish National Individual Registry, all causes of loss of life entered in the National Danish Factors behind Death Registry, and medical records from hospitals and general practitioners. Information on these and various other end points are given in the Supplementary Appendix.9 GRCh37.p5) .Nearly half the deaths in the screening group happened among males with cancers detected during screening, and in 74 percent of these men, the diagnosis was made in the first round of screening. Approximately 25 percent of the deaths happened among guys with cancers detected between screenings, with a similar number among unscreened men. We performed an analysis of the influence of the center by calculating the rate ratios for loss of life from prostate cancers, omitting each center individually . The overall rate ratios remained significant, with a spot estimate of the rate ratio that was near 0.80, of the exclusion of the seven centers irrespective.