Researchers studied both of these types of cells in the laboratory. They discovered that a proteins expressed by abnormalities in a gene linked to motor neurone disease, which is called TDP-43, triggered the astrocytes to die. The scholarly research, led by the University of Edinburgh and funded by the Electric motor Neurone Disease Association, provides fresh new insight into the mechanisms mixed up in disease. Although TDP-43 mutations certainly are a rare cause of motor neurone disease , researchers are especially interested in the gene because in almost all MND patients, TDP-43 protein forms pathological clumps inside motor neurons.Gardy, Ph.D., James C. Johnston, M.D., Shannan J. Ho Sui, Ph.D., Victoria J. Make, M.D., Lena Shah, M.Sc., Elizabeth Brodkin, M.D., Shirley Rempel, R.N., Richard Moore, Ph.D., Yongjun Zhao, D.V.M., Robert Holt, Ph.D., Richard Varhol, M.Sc., Inanc Birol, Ph.D., Marcus Lem, M.D., Meenu K. Sharma, Ph.D., Kevin Elwood, M.D., Steven J.M. Jones, Ph.D., Fiona S.L. Brinkman, Ph.D., Robert C. Brunham, M.D., and Patrick Tang, M.D., Ph.D.: Whole-Genome Social-Network and Sequencing Evaluation of a Tuberculosis Outbreak Mycobacterium tuberculosis can be an important infectious disease actually in developed countries with comprehensive control programs. This is the case in British Columbia, Canada, where in fact the 2007 incidence rate of 6.4 cases per 100,000 human population exceeded the national average of 4.7 cases per 100,000 population.1 IN-MAY 2006, a case of smear-detrimental pleural tuberculosis was diagnosed within an adult in a medium-size community in British Columbia.